In humans, as well as in other mammals, there are two distinct TPH genes. In humans, these genes are located on chromosomes 11 and 12 and encode two different homologous enzymes TPH1 and TPH2 (sequence identity 71%). • TPH1 is mostly expressed in tissues that express serotonin (a neurotransmitter) in the periphery (skin, gut, pineal gland) but it is also expressed in the central nervous system.
WikiGenes - TPH2 - tryptophan hydroxylase 2
SpletPromoter2.0 Prediction Server ( cbs.dtu.dk/services/pro) Soft Berry ( softberry.com ), 网上还提供了一些常见基因的数据库:. 真核启动子数据库第85版(The Eukaryotic Promoter … Splet07. dec. 2024 · [ PMID 17568567] rs11178997 significantly reduced TPH2 transcriptional activity by 22% and 7% in cell lines might have implications for the development and function of the serotonergic system in the brain. paper Carriers of the A-Allele of rs11178997 showed a decreased cortisol and ACTH stimulation. might be crucial factors … dskp chemistry form 4 pdf download
TPH2 - an overview ScienceDirect Topics
http://www.larc.tsinghua.edu.cn/post/971/31 SpletOther interactions of TPH2. The major finding of this study was the high expression level of TPH2 mRNA in the raphe nuclei ( approximately 4-fold more abundant than that of TPH1) … Splet26. nov. 2024 · Serotonin (5-HT) is a hormone and neurotransmitter that modulates neural activity as well as a wide range of other physiological processes including cardiovascular … commercial playground sand digger