WebNov 24, 2013 · Although targeted genome modification (TGM) in plants was first demonstrated in the late 80s, it remained for a long time far from routine because of its low efficiency (Paszkowski et al. 1988).Very recently, revolutionary advances in the engineering of site-specific nucleases (SSNs) have allowed progress to be made in the precise … WebMay 28, 2024 · Modification of the Per2 clock gene in mPer2 Luc reporter mice significantly alters circadian function. Behavioral period in constant dark is lengthened, and …
Targeted modification of the Per2 clock gene alters …
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