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Ptpmt1 hypoxia

WebNov 4, 2024 · PTPMT1 and cardiolipin levels were significantly reduced in Sugen/hypoxia mice, while miR-150 supplementation restored their expression to the level seen in healthy mice (Figures 6A–6C). Overexpression of PTPMT1 and miR-150 significantly elevated cardiolipin levels in cultured endothelial cells (p < 0.01 and p < 0.05, respectively) ( Figure … WebCM-H 2 DCFDA staining showed that ROS accumulated more dramatically in PTPMT1 KO cells under hypoxia than in normoxia ( Figures 2E and S1H). MitoPY1 is a small-molecule fluorescent probe that ...

Ptpmt1 induced by HIF-2α regulates the proliferation and …

WebNov 4, 2024 · PTPMT1 and cardiolipin levels were significantly reduced in Sugen/hypoxia mice, while miR-150 supplementation restored their expression to the level seen in healthy … WebNov 1, 2024 · PTPMT1 and car diolipin levels w ere significantly reduced in Suge n/hypoxia mice, while 196 miR-150 supplementation restored their expression to the level seen in healthy mice ( Figure princetop corporate training https://wildlifeshowroom.com

Ptpmt1 induced by HIF-2α regulates the proliferation and glucose ...

WebOct 1, 2015 · In this study, we presented evidence that mitochondrial phosphatase Ptpmt1 is a hypoxia response molecule that regulates cell proliferation, survival and glucose … WebFeb 10, 2015 · Lysates from ptpmt1 +/ ... SDH activity, supercomplex distribution in the mitochondria, and metabolic adaptation of mitochondria to starvation or hypoxia/reoxygenation (Acín-Pérez et al., 2014). Therefore, in addition to increasing glucose uptake by stimulating insulin secretion, PTPMT1 inhibition may increase the rate of … WebMar 15, 2024 · Download Citation PTPMT1 regulates mitochondrial death through the SLC25A6-NDUFS2 axis in pancreatic cancer cells Pancreatic ductal adenocarcinoma is a highly malignant cancer with poor ... prince topher full name

Genome-wide CRISPR-Cas9 knockout library screening identified …

Category:miR-150-PTPMT1-cardiolipin signaling in pulmonary …

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Ptpmt1 hypoxia

Role of endothelial microRNA-150 in pulmonary arterial …

WebMar 18, 2016 · In this study, we presented evidence that mitochondrial phosphatase Ptpmt1 is a hypoxia response molecule that regulates cell proliferation, survival and glucose … WebMar 5, 2024 · PTPMT1 and cardiolipin levels were significantly reduced in Sugen/hypoxia mice, while miR-150 supplementation restored their expression to the level seen in healthy mice (Figures 6 A–6C). Overexpression of PTPMT1 and miR-150 significantly elevated cardiolipin levels in cultured endothelial cells (p < 0.01 and p < 0.05, respectively) ( Figure ...

Ptpmt1 hypoxia

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WebMar 18, 2016 · In this study, we presented evidence that mitochondrial phosphatase Ptpmt1 is a hypoxia response molecule that regulates cell proliferation, survival and glucose metabolism in human erythroleukemia TF-1 cells. Exposure to hypoxia or DFO treatment results in upregulation of HIF1-α, HIF-2α and Ptpmt1. Only inhibition of HIF-2α by shRNA ... Webidentify PTPMT1, an important gene for hypoxic survival of HCC cells. PTPMT1 synthesizes cardiolipin, a crucial component of mitochondrial membrane, to maintain mitochondrial integrity, trap electrons, and prevent excessive ROS accumulation under hypoxia. PTPMT1 is a targetable vulnerability to combat hypoxic cancers. Bao et al., 2024, Cell ...

WebNov 4, 2024 · Beneficial effects of miR-150 in vitro and in vivo were linked with PTPMT1-dependent biosynthesis of mitochondrial phospholipid cardiolipin and reduced expression … WebJun 8, 2011 · PTPMT1 was the first protein tyrosine phosphatase found localized to the mitochondria, but its biological function was unknown. Herein, we demonstrate that whole body deletion of Ptpmt1 in mice leads to embryonic lethality, suggesting an indispensable role for PTPMT1 during development. Ptpmt1 defic …

WebMar 21, 2024 · Genome-wide CRISPR-Cas9 knockout library screening identified PTPMT1 in cardiolipin synthesis is crucial to survival in hypoxia in liver cancer. Splicing factor SRSF1 … WebNov 4, 2024 · Endothelium-targeted miR-150 delivery prevented the disease in Sugen/hypoxia mice, while endothelial knockdown of miR-150 had adverse effects. miR-150 target genes revealed significant associations with PAH pathways, including proliferation, inflammation, and phospholipid signaling, with PTEN-like mitochondrial phosphatase …

WebJan 3, 2013 · Here we report that depletion of PTPMT1, a PTEN-like mitochondrial phosphatase, in inducible or hematopoietic-cell-specific knockout mice resulted in hematopoietic failure due to changes in the cell cycle and a block in the differentiation of HSCs. Surprisingly, the HSC pool was increased by ∼40-fold in PTPMT1 knockout mice.

WebSpecifically, PTPMT1 knockout cells exhibited slower growth, lower viability, and less aggressive phenotypes both in vitro and in vivo – and hypoxia enhanced these changes. … prince topspin 15lWebFeb 1, 2016 · Furthermore, atypical DUSP PTPMT1 is induced in response to hypoxia by hypoxia-inducible factor HIF-2α in erythroid leukemia cells, and its inhibition induces … plug shortsWebMar 25, 2024 · PTPMT1 mediates homeostatic effects of miR-150 . Transfection of HPAECs with miR-150 markedly attenuated endothelial cell apoptosis, hypoxia-induced cell proliferation and hypoxia- and TNF-α-induced NFκB activation (Figure 4A-E). In contrast, inhibition of miR-150 markedly augmented endothelial damage and prince top album