WebJul 12, 2024 · Chimeric antigen receptors (CARs) repurpose natural signaling components to retarget T cells to refractory cancers, but have shown limited efficacy against solid tumors. Here, we introduce ‘CAR Pooling’, a multiplexed approach to rapidly identify CAR designs with clinical potential. Forty CARs with diverse immune costimulatory domains were … http://earth.tju.edu.cn/info/1459/8913.htm
Pooled screening of CAR T cells identifies non-native ... - bioRxiv
Web4-Hydroxyphenylpyruvate dioxygenase (HPPD) is an important target for herbicide design. A multilayered virtual screening workflow was constructed by combining two pharmacophore models based on ligand and crystal complexes, molecular docking, molecular dynamics (MD), and biological activity determination to identify novel small-molecule inhibitors of … WebWe demonstrate multiple applications of REDMAP, including dynamic on/off control of the endogenous Ras/Erk mitogen-activated protein kinase (MAPK) cascade and control of … dneu-i220
A smart insulin-sensor device for correcting insulin …
WebHaifeng Ye With the increasingly dominant role of smartphones in our lives, mobile health care systems integrating advanced point-of-care technologies to manage chronic diseases are gaining attention. WebAug 9, 2016 · Haifeng Ye Nature Biotechnology (2024) A fully human transgene switch to regulate therapeutic protein production by cooling sensation WebHaifeng Ye; ADD TO READING LIST Abstract PDF Supporting Information. Biochemistry. Research Article August 20, 2024. Cryo-EM structures of Escherichia coli cytochrome bo 3 reveal bound phospholipids and ubiquinone-8 in a dynamic substrate binding site. dneven prestoj skopje