WebSep 1, 2009 · The overall prediction success rate was 86% for CYP3A4 inhibition and induction in zebrafish, 100% for CYP3A4 inhibition and 71% for CYP3A4 induction … WebMetabolic activation is the primary cause of chemical toxicity including hepatotoxicity. Cytochrome P450 2E (CYP2E) is involved in this process for many hepatotoxicants, including acetaminophen (APAP), one of the most common analgesics and antipyretics. Although the zebrafish is now used as a model for toxicology and toxicity tests, the …
Ethoxyresorufin-O-Deethylase - an overview ScienceDirect Topics
WebNov 1, 2024 · Several Cyp enzymes are induced, among others, by agonists of the arylhydrocarbon receptor (AhR) such as PAHs. Cyp1a, cyp1b1, cyp1c1 and cyp1c2 were chosen to be quantified at the RNA level in zebrafish embryos during 24 … WebCytochrome P450-dependent biotransformation capacities in embryonic, juvenile and adult stages of zebrafish (Danio rerio)-a state-of-the-art review. Given the strong trend to … towse court
Cytochrome P450-mediated 17β-estradiol metabolism in …
WebAs we demonstrate, whole-mount zebrafish embryo CYP1A induction by the AHR ligand retene is easily detected by mAb CRC4, with the vasculature being a sensitive target. ... Reed, L.; Arlt, V.M.; Phillips, D.H. The role of cytochrome P450 enzymes in carcinogen activation and detoxication: An in vivo–in vitro paradox. Carcinogenesis 2024, 39 ... WebNational Center for Biotechnology Information WebTogether with levels of CYP1A protein and mRNA, the induction of CYP1A catalytic activities may be used both for the assessment of exposure and as early-warning sign for potentially harmful effects of many organic trace pollutants. towse k9 solutions