Ctr1 inhibitor
WebOct 1, 2013 · The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity. N. Pabla, R. Murphy, Kebin Liu, Z. Dong Biology, Chemistry American journal of physiology. Renal physiology 2009 TLDR WebNov 6, 2012 · CTR1 consists of a unique N-terminal regulatory domain and a C-terminal serine/threonine kinase domain ( Fig. 1 A ). Because CTR1 is most similar in sequence …
Ctr1 inhibitor
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High affinity copper uptake protein 1 (CTR1) is a protein that in humans is encoded by the SLC31A1 gene. Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, and intracellular co… WebC1 esterase inhibitor (C1INH) is a plasma protein that prevents complement activation, inhibits proteases in the coagulation system such as factors XIa, XIIa and kallikrein, …
WebIntratympanic administration of copper sulfate, a CTR1 inhibitor, or knockdown of CTR1 with small inter- fering RNA can decrease the uptake and cytotoxicity of cisplatin and prevent hearing loss caused by cisplatin, both in vitro and in vivo [31]. WebOct 15, 2010 · The Ctr1 protein is a high-affinity Cu+ importer that is structurally and functionally conserved in yeast, plants, fruit flies, and humans and that, in all of these …
WebCTR1 phosphorylates the C-terminal domain of EIN2, preventing its nuclear translocation that activates downstream ethylene signaling. Without ethylene, EIN2 is constantly targeted for the ubiquitin proteasome–dependent degradation pathway ( 15 – 19 ). WebCopper transporter 1 (CTR1) represents an important determinant of cisplatin resistance. A series of 35 semi-substituted steroids were recently investigated on cisplatin-resistant …
WebAntibodies that detect CTR1 can be used in several scientific applications, including Western Blot, Immunohistochemistry, ELISA, Immunoprecipitation and Immunocytochemistry. …
WebThe possibility of local administration of CTR1 inhibitors during cisplatin therapy as a means of otoprotection is thereby raised. AB - The goal of this study was to determine the role of an influx copper transporter, CTR1, in the ototoxicity induced by cisplatin, a potent anticancer platinum analog used in the treatment of a variety of solid ... how long can a abscess tooth lastWebThere is no significant difference between the two groups with or without CTR1 inhibitor, while cisplatin was inhibited by CTR1 inhibitor (Supplementary Figure S3), suggesting the cisplatin... how long can a 4 year old sustain attentionWebNational Center for Biotechnology Information how long can a 2x6 ceiling joist spanWebMay 5, 2024 · In this model, CTR1 is a negative regulator of signaling. Ethylene functions as an inverse agonist, where it inhibits the receptors, which leads to lower activity of CTR1 releasing downstream components from inhibition by CTR1. how long can aa battery lasthow long can a aquatic turtle be out of waterWebDec 12, 2024 · Studies of cisplatin-induced ototoxicity and cochlear uptake show that it can be modulated by administration of a CTR1 inhibitor, copper sulfate. In mice, intratympanic administration of copper sulfate given before intraperitoneal cisplatin dosing prevented subsequent hearing loss. how long can a 9 week old puppy hold bladderWebJan 23, 2024 · CTR1 inhibition results in a mild reduction in available copper, and ATP7A knockdown results in copper accumulation in the cells (Table 1). Disruption … how long can a 501c3 be inactive